One Month on Huel Trials - Two Subjects

Update: These assessments were done using Huel v1.2 figures. We have now updated our formula to v3.0, which you can view here.

Principal aim

Two individuals to consume Huel, a nutritionally complete powdered food as sold on Huel.com, as their sole source of nutrition for 30 days to demonstrate nutritional benefits of Huel by way of blood screening, anthropometric measurements and feedback.

Aims

Favourable body weight, BMI, WHR and %BF outcomes
Favourable biochemical, haematological and endocrinological marker outcomes
Positive feedback on the physical, social and mental well-being of subject

Assessments

Essential blood screening including urea and electrolytes, principle protein markers, glucose, insulin, thyroid function markers, haematology and liver function tests.
Body weight (kg)
Body Mass Index (BMI) (kg/m2)
Waist Hip Ratio (WHR)
Four site skinfold thickness (SFT) tests to calculate percentage body fat (%BF)
Food, feelings & symptoms food diaries
Subject interviews

Methodology & Design

Two volunteers were selected in respect of them having no significant past medical history, an active lifestyle, professional occupations, normal BMI, no food intolerances and normally consumed a varied omnivorous diet.

On the day they commenced the trial, the following were taken:

Fasting blood through Medichecks.com for essential blood screening, serum insulin and thyroid function tests. See the Results Tables below for which blood markers were screened.

Anthropometric measurements:

Body weight (kg)
Height (m)
Waist Hip Ratio WHR (cm)
Four site skinfold thickness: triceps, biceps, subscapular and suprailiac skin folds in order to assess percentage body fat

Diet History

Lifestyle interview including exercise

At the interview, the assessor provided each subject with a plan of how much Huel to consume and each was requested to keep a short diary noting how they felt and what their stools were like each day. Each subject completed a consent form and disclaimer (Appendix 1). Each subject participated in the trial in January and February 2016 for 30 days. Follow-up email correspondence occurred between the assessor and the subjects throughout the trial. On the final day of the trial, the following were taken:

Fasting blood through Medichecks.com for essential blood screening, serum insulin and thyroid function tests.

Anthropometric measurements:

Body weight (kg)
Height (m)
Waist Hip Ratio WHR (cm)
Four site skin-fold thickness: triceps, biceps, subscapular and suprailiac skin folds in order to assess percentage body fat

Interview regarding feedback of the trial.

Collection of the food diaries.

Subject Report

Subject 1

Subject 1 was a 27 year old male who had not previously used Huel. He had a relatively sedentary 9-5 job and exercised three x 5km jogs per week.

Diet History:

Wake 08.00

09.30: Fruit or bacon roll + black coffee

12.30: Sandwich or soup (white bread), occasionally crisps + Diet Coke or water

Mid-afternoon: occasional chocolate bar

Evening meal: Monday-Thursday: vegetable curry; Friday-Sunday: take-away

Evening snacks: Twiglets or biscuits

Bedtime 22.00-23.00

Alcohol at weekends and occasional binge

Trial Plan:

Wake: Glass water

Breakfast 8.00am: 114g (3 scoops) Huel

10.30am: 76g (2 scoops) Huel

13.00: 76g (2 scoops) Huel

15.30: 76g (2 scoops) Huel

18.00: 114g (3 scoops) Huel

Hour before bed: 76g (2 scoops) Huel

Total: 532g (14 level scoops) of Huel per day

In addition: 6 cups of fluid per day minimum

Exercise: 5 km jog 5 days per week

After 5 days on the trial, Subject 1 was reviewed and the Huel was reduced by 2 scoops per day to a total of 380g (12 scoops) per day. He was feeling bloated on 14 scoops.

Subject 1 Feedback:

Subject 1 used vanilla Huel throughout and blended the Huel each evening for the following day: he found this easier and more pleasant. He reported following the plan to be hard to begin with but also that he ‘felt great’.

He consumed 3-4 mugs of black coffee per day during the trial. He also used sugar-free chewing gum which he found particularly pleasant to use a short while after a Huel meal.

He reported to have cravings for other foods when others around him were eating, especially at work. He particularly craved savoury foods and was looking forward to consuming something savoury after the trial. At the start of the trial he reported to feel full before the second Huel meal, but was craving solid food by lunchtime, but later in the day was ‘not bothered by the lack of regular food’.

Exercise, for the first few days only, was reported to be ‘hard’, but after a week, he was running 5 km in less than 28 minutes. On trial day 30, he ran 5 km in 24 mins 20 secs.

He stated that he is usually a poor sleeper but felt he slept better during the trial. It was of his opinion, that this may have been due to having both a better eating and exercise routine as well as more favourable nutrition.

Subject 1 also reported that previously he suffered from frequent headaches, but during the trial had not had them and had not taken paracetamol once. He felt this may have been due to Huel or the fact that he consumed no alcohol during the trial.

His bowel movements were firm throughout, although irregular with some days not opening them, and other days opening them up to four times.

His main struggle was with the social side of Huel; he found this challenging and limiting. Not being able to consume food with friends when socialising he found very difficult, and craved for what they were eating around him.

By the end of the trial, Subject 1 reported, in response to the question ‘How did you feel in general?’, ‘Really great! I feel the best I have done in a long time. My sleep patterns are regular, I don’t get headaches, and I have been satisfied and still enjoying the Huel.’

He stated that he wanted to continue to use Huel after the trial, but at about 80% of his total food intake. He felt that it would have been nice to have been able to blend fruit with Huel.

Subject 2

Subject 2 was a 25 year old male who exercised 4-5 times per week with a mixture of weight resistance training and cardiovascular exercise, typically for over an hour per session. He had not previously used Huel. He had a relatively a sedentary 9-5 job.

Diet History:

Wake 07.00 : Weetabix 40-50g with semi-skimmed milk + tea with semi-skimmed milk, no sugar

Mid-morning: occasional piece of fruit

12.15: rice or couscous with chicken, turkey, sausage or bacon and salad

Mid-afternoon: occasional piece of fruit

Post exercise: Dymatize Iso 100 protein powder supplement with water

Evening meal varied from 18.00-20.00: pasta, potato or sweet potato + vegetables + meat

Bed 23.00

Daily: up to 10 mugs of tea with semi-skimmed milk

Alcohol drunk socially at weekends and on Thursday evenings when playing pool

Weekly: include some fast food

Trial Plan:

Wake: Glass water

Gym 5 x gym sessions per week: combination of weight training and cardiovascular exercise

Breakfast 07.00: 114g (3 scoops) Huel

10.30: 76g (2 scoops) Huel

Lunch 13.00: 76g (2 scoops) Huel

15.30: 76g (2 scoops) Huel

18.00: 76g (2 scoops) Huel

Hour before bed: 76g (2 scoops) Huel

Total: 494g (13 level scoops) of Huel per day

In addition: 6 cups of fluid per day minimum

Subject 2 Feedback:

Subject 2 used vanilla Huel and also included the Huel Natural Flavour System flavours as he desired variety. He reported to be most fond of the strawberry and toffee flavours added to vanilla Huel.

One issue Subject 2 had was adhering to the timings as per the prescribed plan. Some days he only consumed 12 scoops of Huel. He also consumed black tea, green tea and plenty of water. He reported Huel to satisfy his hunger, but he was ready for Huel at the meal times stipulated.

He found the main drawback with a 100% Huel diet was how it affected his socialising, especially doing things with his partner, who he reported to have ‘suffered’; for example, previously they would have have visited the cinema and had a meal out; on the Huel diet, they just visited the cinema.

Subject 2 also enjoys cooking and missed not doing this on the trial.

He reported to have found sticking to a 100% Huel diet quite hard psychologically in one sense, but he did feel he felt sharper mentally, more confident and felt his physique and muscularity had improved. When performing exercise, he felt he was stronger and more powerful. He was previously doing 3-4 pull-ups, but this increased to around 15 repetitions. He also felt his injuries were ‘better’. He reported that he felt most of the benefits to exercise performance occurred during the beginning of the trial and progress plateaued later.

He reported there to be a significant cost saving and worked out that, even if he had have been purchasing the Huel, he would have saved well over £200 in a month.

He reported to have had 2-3 days where he had loose stools. He did report notable flatulence. For the last week of the trial, he had a viral infection which made him feel very rough.

Subject 2 assessed his mood throughout the trial and found it a positive experience. On days where his mood was low, it was more being due to feeling tired and hungry.

He stated that he wanted to continue to use Huel after the trial, but would be re-introducing some solid food. He felt he could participate in a 3 month trial on 100% Huel, but wasn't sure if he could cope with 12 months: this was more to do with socialising and events.

Results Table

Subject 1

Factor	Unit	Ref Range	Initial	Final
Red Blood Cells
Haemoglobin	g/L	130-170	168	149
HCT		0.37.0.50	0.544*	0.458
Red Cell Count	x10^12/L	4.40-5.80	5.3	4.85
MCV	fL	80-99	102.6*	94.4
MCV	fL	80-99	102.6*	94.4
MCH	pg	26.0-33.5	31.7	30.7
MCHC	g/L	300-350	309	325
RDW		11.5-15.0	13.0	12.6

Factor	Unit	Ref Range	Initial	Final
White Blood Cells
White Cell Count	x10^9/L	3.0-10.0	8.23	14.04*
Neutrophils	x10^9/L	2.0-7.5	5.41	10.91*
Lymphocytes	x10^9/L	1.2-3.65	2.13	2.13
Monocytes	x10^9/L	0.2-1.0	0.59	0.95
Eosinophils	x10^9/L	0.0-0.4	0.09	0.01
Basophils	x10^9/L	0.0-0.1	0.01	0.03

Factor	Unit	Ref Range	Initial	Final
Clotting Cells
Platelet Count	x10^9/L	150-500	243	216
MPV		7-13	12.8	13.5*

Factor	Unit	Ref Range	Initial	Final
Kidney Function
Sodium	mmol/L	135-145	143	141
Potassium	mmol/L	3.5-5.0	n/a	5.5*
Chloride	mmol/L	98-107	96*	94*
Bicarbonate	mmol/L	22.29	25	27
Urea	mmol/L	1.7-8.3	4.2	3.7
Creatinine	umol/L	66-112	94	68

Factor	Unit	Ref Range	Initial	Final
Liver Function
Bilirubin	umol/L	0.20	8.0	10.0
ALP	IU/L	40-129	102	113
AST	IU/L	0-37	31	31
ALT	IU/L	10-50	55*	87*
CK	IU/L	38-204	103	276*
Gamma GT	IU/L	10-71	47	21

Factor	Unit	Ref Range	Initial	Final
Proteins
Total Protein	g/L	63-83	78	74
Albumin	g/L	34-50	52*	53*
Globulin	g/L	19-35	26	21
Uric Acid	g/L	266-474	301	412

Factor	Unit	Ref Range	Initial	Final
Minerals
Calcium	mmol/L	2.20-2.60	2.55	2.52
Corrected Calcium	mmol/L	2.20-2.60	2.43	2.38
Phosphate	mmol/L	0.87-1.45	2.11*	1.11
Iron	umol/L	10.6-28.3	33.1*	22.1
TIBC	umol/L	41-77	73	66
Transferrin Saturation	%	20-55	45	33

Factor	Unit	Ref Range	Initial	Final
Diabetes
Fasting Blood Glucose	mmol/L	3.5-5.8	4.5	3.9
Insulin	mlU/L	2.6-24	3.6	2.0*

Factor	Unit	Ref Range	Initial	Final
Lipids
TGs	mmol/L	<2.3	1.2	0.7
TC	mmol/L	<5.0	4.8	3.2
HDL	mmol/L	0.9-1.5	1.2	0.9
LDL	mmol/L	<0.3	3.1*	2.0
HDL %	%	>20	25	28

Factor	Unit	Ref Range	Initial	Final
Thyroid
TSH	mlU/L	0.27-4.2	1.42	1.51
Free T4	pmol/L	12.0-22.0	17	17.8
Free T3	pmol/L	3.1-6.8	5.8	5.9

Factor	Unit	Ref Range	Initial	Final
Anthropemetry
Weight	kg	-	77.9	72.3
Height	m	-	1.75	1.75
BMI	kg/m2	18.5-24.9	25.4	23.6
WHR	cm	0.90-0.99	0.99	0.94
Body Fat	%	14.0-19.9	17.5	15.0

Subject 2

Factor	Unit	Ref Range	Initial	Final
Red Blood Cells
Haemoglobin	g/L	130-170	134	136
HCT		0.37.0.50	0.41	0.408
Red Cell Count	x10^12/L	4.40-5.80	4.54	4.6
MCV	fL	80-99	90.3	88.7
MCH	pg	26.0-33.5	29.5	29.6
MCHC	g/L	300-350	327	333
RDW		11.5-15.0	12.4	12.9

Factor	Unit	Ref Range	Initial	Final
White Blood Cells
White Cell Count	x10^9/L	3.0-10.0	5.7	5.61
Neutrophils	x10^9/L	2.0-7.5	3.25	2.96
Lymphocytes	x10^9/L	1.2-3.65	1.86	2.19
Monocytes	x10^9/L	0.2-1.0	0.34	0.23
Eosinophils	x10^9/L	0.0-0.4	0.21	0.21
Basophils	x10^9/L	0.0-0.1	0.04	0.03

Factor	Unit	Ref Range	Initial	Final
Clotting Cells
Platelet Count	x10^9/L	150-500	202	215
MPV		7-13	11.7	11.8

Factor	Unit	Ref Range	Initial	Final
Kidney Function
Sodium	mmol/L	135-145	144	141
Potassium	mmol/L	3.5-5.0	n/a	4.8
Chloride	mmol/L	98-107	102	100
Bicarbonate	mmol/L	22.29	25	25
Urea	mmol/L	1.7-8.3	6.8	6.9
Creatinine	umol/L	66-112	83	90

Factor	Unit	Ref Range	Initial	Final
Liver Function
Bilirubin	umol/L	0.20	9.0	21*
ALP	IU/L	40-129	73	55
AST	IU/L	0-37	20	79
ALT	IU/L	10-50	18	47
CK	IU/L	38-204	340*	3808*
Gamma GT	IU/L	10-71	153	14

Factor	Unit	Ref Range	Initial	Final
Proteins
Total Protein	g/L	63-83	72	72
Albumin	g/L	34-50	50	51*
Globulin	g/L	19-35	22	21
Uric Acid	g/L	266-474	339	522*

Factor	Unit	Ref Range	Initial	Final
Minerals
Calcium	mmol/L	2.20-2.60	2.39	2.41
Corrected Calcium	mmol/L	2.20-2.60	2.31	2.31
Phosphate	mmol/L	0.87-1.45	1.05	1.01
Iron	umol/L	10.6-28.3	16.6	19.6
TIBC	umol/L	41-77	55	58
Transferrin Saturation	%	20-55	30	34

Factor	Unit	Ref Range	Initial	Final
Diabetes
Fasting Blood Glucose	mmol/L	3.5-5.8	4.1	4.0
Insulin	mlU/L	2.6-24	23.9	1.2*

Factor	Unit	Ref Range	Initial	Final
Lipids
TGs	mmol/L	<2.3	0.8	0.6
TC	mmol/L	<5.0	3.5	3.0
HDL	mmol/L	0.9-1.5	1.5	1.3
LDL	mmol/L	<0.3	1.6	1.4
HDL %	%	>20	43	43

Factor	Unit	Ref Range	Initial	Final
Thyroid
TSH	mlU/L	0.27-4.2	1.83	2.15
Free T4	pmol/L	12.0-22.0	19.7	20.8
Free T3	pmol/L	3.1-6.8	5.1	4.9

Factor	Unit	Ref Range	Initial	Final
Anthropometry
Weight	kg	-	80.5	75.5
Height	m	-	1.81	1.81
BMI	kg/m2	18.5-24.9	24.4	23.1
WHR	cm	0.90-0.99	0.93	0.92
Body Fat	%	14.0-19.9	11.8	8.9

* indicates outside reference range

Discussion of Observations

Both subjects found consuming 100% Huel and no other foods with nutritional value for 30 days generally a positive experience and had no significant adverse reactions physiologically, biochemically or psychologically.

Subject 1 had two haematological readings that were elevated prior to the trial, but improved afterwards. He did display increased neutrophils after the trial, indicating presence of an infection. His potassium level was elevated slightly but we have no pre-trial reading to compare this to; this may be due to medical issues or, more likely, is due to rupture of blood cells in the sample. His chloride level was slightly low before and after the trial. He did display slightly elevated ALT and CK liver enzyme levels after the trial; the ALT was slightly raised before the trial. These levels may have been raised in response to recent hard exercise (he reported achieving a personal best running time on the last day of the trial prior to the blood sample being taken) or possible infection.

Subject 1 displayed an improved LDL cholesterol level indicating a slight reduced risk of cardiovascular disease. His serum insulin was marginally low at the end of the trial.

Subject 1 wanted to lose some weight and body fat through the trial and achieved these goals with a 5.6 kg weight loss and 2.5% drop in body fat, also improving his BMI. His WHR also improved. These benefits would be in line with reduced disease risk.

Subject 2 showed elevated liver enzymes, especially CK which was extremely raised, bilirubin, serum albumin and uric acid at the end of the trial. He reported to have had a viral infection for the final week of the trial, so it’s likely that this was the cause of these readings. His serum insulin was also very low on the final reading, which could be explained by a hypermetabolic state in the presence of infection. Other markers were in the correct, healthy ranges.

Subject 2 wanted to lose some weight and body fat through the trial and achieved these goals with a 5 kg weight loss and 2.9% drop in body fat, also lowering his BMI. His WHR also improved. These benefits would be in line with reduced disease risk.

Both subjects found adhering to a 100% Huel nutrition diet challenging with the main limitations being the the social aspects of food. Both had normally formed stools, for the main, but did report flatulence.

Conclusion Summary

Following a 100% Huel diet for 30 days with regular exercise gave no adverse blood marker reactions in either subject and any observed could be explained by the effects of exercise or infection. There were small improvements to blood lipid markers and desirable results for body weight, BMI, WHR and percentage body fat which together may indicate a slight improvement in cardiovascular and other disease risk.

Both subjects reported that they felt better on a diet where Huel provided 100% of their nutrition, although both acknowledged this may have been due to following a consistent regimen and not solely due to the nutrition provided by Huel. The main challenge reported was the limitations a 100% Huel diet puts on socialising. Both successfully adhered to their nutrition plans, but did find doing so challenging and felt that Huel being a significant part of daily nutrition, rather than 100%, would be a more suited to their lifestyles. Both wish to continue using Huel on this basis.

Appendix 1 - Health Questionnaire and Disclaimer

Note: this is a questionnaire that illustrates what was sent to the participants to the original study.

Name:
Address:
Telephone number:
Date of Birth:
Sex:
Have you been told by a doctor that you have or have had any of the following? (please tick any that apply)

Diabetes
High blood pressure
Heart disease
Liver disease
Lung disease
Cancer
Kidney disease
Digestive disorders (please specify)
Others (please specify)

Are you currently using any medication?
If YES, please specify which and for what reasons:
Do you exclude any foods for cultural, ethnic or other personal reasons?
If yes, which foods?
Do you have any diagnosed food allergies or intolerances?
If YES please give details:
To the best of your knowledge, do you have any intolerances to the following:

Sunflower oil
Rice
Peas
Oats
Coconuts
Flaxseed
Oats

Do you currently partake in any regular exercise? If so, what and how regularly?

Points to Note about the Trial

The trial will involve you consuming a diet consisting solely of Huel for 30 days.

You will not be permitted to consume anything else other than water, black tea, green tea or black coffee other than Huel for 30 days.

You will be required to have blood taken on the day before the trial and on the final day of the trial. You will have to attend a specific private hospital nearby to have these taken. It is essential that you attend on these specific days.

You will have to attend an appointment (30-60 mins in duration) with the Huel Registered Nutritionist in Corby, Northants on the day before the trial and on the final day of the trial who will take some anthropometric measurements (weight, callipers, tape measure) and ask you some questions.

The nutritionist will also discuss Huel requirements and will inform you the amount of Huel to consume each day.

You will be required to perform some light exercise as part of this trial. What you do will be based on your current level of exercise and will be discussed with the nutritionist.

You will be required to complete a food and feelings diary daily during the trial - this will involve just a couple of sentences recorded each day.

Sufficient Huel for the 30 days will be supplied free of charge. All travel costs for appointments concerning this trial will be reimbursed at the end of the trial

Please return this completed questionnaire to xxx. By completing this questionnaire, you agree that you’re happy to participate in the trial as outlined above.